Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSRHLC)

Drug Name

3-(phenylsulfonyl)-1-(piperidin-3-yl)-1H-indole Drug Info

Synonyms

CHEMBL1076583; 651335-52-3; 3-(phenylsulfonyl)-1-(piperidin-3-yl)-1H-indole; SCHEMBL4077273; CTK1J9031; DTXSID60434701; BDBM50313130; 1H-Indole, 3-(phenylsulfonyl)-1-(3-piperidinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10042892
CAS Number: CAS 651335-52-3
TTD Drug ID: DMSRHLC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 6 receptor (HTR6)	TTJS8PY	5HT6R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 6 receptor (HTR6)	DTT	HTR6	5.594	5.781	5.271	3.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 6 receptor (HTR6)	DTT	HTR6	1.23E-05	-0.12	-0.71

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60.