Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSTL12)

Drug Name

RG7232 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Dyslipidemia	5C80-5C81	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ATP-binding cassette transporter A1 (ABCA1)	TTJW1GN	ABCA1_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
ATP-binding cassette transporter A1 (ABCA1)	DTT	ABCA1	6.113	4.838	4.44	3.104

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Dyslipidemia

ICD Disease Classification

5C80-5C81

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ATP-binding cassette transporter A1 (ABCA1)	DTT	ABCA1	4.88E-01	-0.1	-0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Analysis of "On/Off" Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):465-73.