General Information of Drug (ID: DMSV6KP)

Drug Name
GSK 679769 Drug Info
Indication
Disease Entry ICD 11 Status REF
Anxiety disorder 6B00-6B0Z Discontinued in Phase 2 [1]
Chemotherapy-induced nausea MD90 Discontinued in Phase 2 [1]
Incontinence MF50.2 Discontinued in Phase 2 [1]
Major depressive disorder 6A70.3 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMSV6KP

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Substance-P receptor (TACR1) TTZPO1L NK1R_HUMAN Antagonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Substance-P receptor (TACR1) DTT TACR1 3.597 4.186 4.271 5.113
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anxiety disorder
ICD Disease Classification 6B00-6B0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Substance-P receptor (TACR1) DTT TACR1 1.94E-01 0.04 0.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51.