Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSXT0H)

Drug Name

ONO-1581 Drug Info

Synonyms

OKY-1581; UNII-Z5E7R0J67C; Oky 1581; Z5E7R0J67C; (E)-2-Methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid sodium salt; 2-Propenoic acid, 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-, sodium salt, (E)-; 75987-18-7; CHEMBL11811; C16H14NO2.Na; SCHEMBL2924563; API0015168; LS-123715; sodium (e)-3-[4-(3-pyridylmethyl) phenyl]-2-methylacrylate; 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid, sodium salt, (E)-isomer

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 23663937
CAS Number: CAS 75987-18-7
TTD Drug ID: DMSXT0H

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thromboxane-A synthase (TBXAS1)	TTKNWZ4	THAS_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thromboxane-A synthase (TBXAS1)	DTT	TBXAS1	5.289	4.615	4.413	3.585

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thromboxane-A synthase (TBXAS1)	DTT	TBXAS1	6.56E-01	0.02	0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors, Bioorg. Med. Chem. Lett. 5(10):1087-1090 (1995).