Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT1RH6)

Drug Name
GMC-283 Drug Info
Synonyms CHEMBL430798; MolPort-042-665-651; GMC-2-83; ZINC14299682; BDBM50078062; Trifluoro-methanesulfonic acid 11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]oxazepin-2-yl ester
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Terminated [1]
Cross-matching ID
PubChem CID
10026300
TTD Drug ID
DMT1RH6

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Antagonist [1]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [1]
Dopamine D5 receptor (D5R) TTS2PH3 DRD5_HUMAN Antagonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine D5 receptor (D5R) DTT DRD5 7.097 6.724 6.896 7.369
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Dopamine D2 receptor (D2R) DTT DRD2 5.345 5.634 5.789 5.901
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Schizophrenia
ICD Disease Classification 6A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.