Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTD16H)

Drug Name

3-(4-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile Drug Info

Synonyms

CHEMBL189389; 546141-91-7; 3-(4-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile; SCHEMBL3922456; CTK1F8523; DTXSID40432285; ZINC13582324; BDBM50151901; Benzonitrile, 3-[4-(2-pyridinyl)-1H-pyrazol-1-yl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9881352
CAS Number: CAS 546141-91-7
TTD Drug ID: DMTD16H

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	3.621	1.888	3.567	4.318

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter