Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTDB62)

Drug Name

3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole Drug Info

Synonyms

3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole; 65347-55-9; 38620-69-8; MLS000093715; SMR000029333; CHEMBL27811; 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole; 3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole; 3-(4-1,2,5,6-tetrahydropyridyl)indole; THPindole; ChemDiv2_002931; AC1Q1GX4; SCHEMBL653742; AC1MC402; CTK5C2597; cid_2761023; BDBM31023; DTXSID20375484; CIRSPTXGPFAXRE-UHFFFAOYSA-N; MolPort-000-159-541; HMS1377F05; ZINC154399; STK801496; 2202AE; SBB092334; BBL010213; MFCD03695471; AKOS000505683; FS-1743; NE12559; CCG-139909

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2761023
CAS Number: CAS 65347-55-9
TTD Drug ID: DMTDB62

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic a... J Med Chem. 1990 Aug;33(8):2087-93.