Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTFV65)

Drug Name

IM-094261 Drug Info

Synonyms

IM-094261; CHEMBL370586; AC1NRUHT; ZINC4624188; STK686670; BDBM50173019; MCULE-9113150619; 4-[4-(4-tert-butylanilino)phthalazin-1-yl]benzamide; 4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benzamide; A3870/0164436; 4-{4-[(4-tert-butylphenyl)amino]phthalazin-1-yl}benzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5298698
TTD Drug ID: DMTFV65

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]
VEGFR1 messenger RNA (VEGFR1 mRNA)	TT1VAUK	VGFR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
VEGFR1 messenger RNA (VEGFR1 mRNA)	DTT	FLT1	4.802	4.95	4.597	3.17

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 2 (KDR)	DTT	KDR	1.98E-01	0.11	0.2
VEGFR1 messenger RNA (VEGFR1 mRNA)	DTT	FLT1	1.64E-05	0.29	0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8.