Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTK4LS)

Drug Name

Triptorelin Drug Info

Synonyms

Gonapeptyl depot (TN)

Indication

Disease Entry	ICD 11	Status	REF
Infertility	GB04	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Prostate cancer	2C82.0	Phase 4	[3]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gonadotropin-releasing hormone receptor (GNRHR)	TT8R70G	GNRHR_HUMAN	Modulator	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Gonadotropin-releasing hormone receptor (GNRHR)	DTT	GNRHR	4.372	3.926	1.433	0.926

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Infertility

ICD Disease Classification

GB04

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Gonadotropin-releasing hormone receptor (GNRHR)	DTT	GNRHR	9.07E-01	0.02	0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Triptorelin FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1177).
3	ClinicalTrials.gov (NCT00633347) Use of Antagonist Versus Agonist GnRH in Oocyte Recipient Endometrium Preparation. U.S. National Institutes of Health.
4	Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1. Endocrine. 2006 Aug;30(1):139-44.