Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU15YV)

Drug Name

6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline Drug Info

Synonyms

CHEMBL415501; 6,7-Dimethoxy-4-(2-methoxyphenoxy)quinoline; 190726-38-6; 6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline; SCHEMBL7487419; CTK0E1594; DTXSID50622690; ZTLZYKICAWTOKI-UHFFFAOYSA-N; BDBM50290848; Quinoline, 6,7-dimethoxy-4-(2-methoxyphenoxy)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 22132763
CAS Number: CAS 190726-38-6
TTD Drug ID: DMU15YV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Platelet-derived growth factor receptor beta (PDGFRB)	DTT	PDGFRB	6.43	6.333	6.671	5.97

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Platelet-derived growth factor receptor beta (PDGFRB)	DTT	PDGFRB	5.35E-10	0.36	0.89

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997).