Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU3YXR)

Drug Name

beta-ergocriptine Drug Info

Synonyms

beta-Ergocryptine; beta-Ergokryptine; EINECS 243-728-6; beta-ergocriptine; 5'alpha(S)-sec-Butyl-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione; AC1L4P6P; GTPL988; YYWXOXLDOMRDHW-SGVWFJRMSA-N; PDSP2_001492; AKOS027307800; LS-64294

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 161309
TTD Drug ID: DMU3YXR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D5 receptor (D5R)	TTS2PH3	DRD5_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D5 receptor (D5R)	DTT	DRD5	7.097	6.724	6.896	7.369

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D5 receptor (D5R)	DTT	DRD5	2.59E-01	-0.06	-0.18
Dopamine D5 receptor (D5R)	DTT	DRD5	8.63E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 988).
2	Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.