Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUB5E8)

Drug Name

7,8-dihydroxy-4-phenyl-2H-chromen-2-one Drug Info

Synonyms

7,8-dihydroxy-4-phenyl-2H-chromen-2-one; 842-01-3; 7,8-Dihydroxy-4-phenylcoumarin; 7,8-dihydroxy-4-phenylchromen-2-one; 2zvj; AC1NTWI0; AC1Q78GB; Oprea1_803491; IFLab1_001650; SCHEMBL1181304; CHEMBL1233867; 4-phenyl-7,8-dihydroxycoumarin; CTK5F1973; 4-phenyl-7,8-dihydroxycoumarine; DTXSID10419942; MolPort-000-852-912; JRVIIPJSVKTPBK-UHFFFAOYSA-N; ZINC406883; HMS1416K22; DNDI1417012; ALBB-015578; BBL029555; 0375AF; STL372126; AKOS005175244; MCULE-8639896630; DB08049; 7,8-dihydroxy-4-phenyl-chromen-2-one; 7,8-DIHYDROXY-4-PHENYL COUMARIN

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5413034
CAS Number: CAS 842-01-3
TTD Drug ID: DMUB5E8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Catechol-O-methyl-transferase (COMT)	TTKWFB8	COMT_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Catechol-O-methyl-transferase (COMT)	DTT	COMT	8.791	7.048	7.478	7.165

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Catechol-O-methyl-transferase (COMT)	DTT	COMT	9.24E-02	0.17	1.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.