Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUETI2)

Drug Name
AMG 167 Drug Info
Indication
Disease Entry ICD 11 Status REF
Osteoporosis FB83.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMUETI2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sclerostin (SOST) TTYRO4F SOST_HUMAN Modulator [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Bone marrow
The Studied Disease Osteoporosis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Sclerostin (SOST) DTT SOST 1.11E-01 0.9 2.87
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01101048) An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density. U.S. National Institutes of Health.
2 Osteoporosis - a current view of pharmacological prevention and treatment. Drug Des Devel Ther. 2013; 7: 435-448.