Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUILX8)

Drug Name

N-(2-phenylimidazo[1,2-a]pyridin-3-yl)benzamide Drug Info

Synonyms

N-(2-phenylimidazo[1,2-a]pyridin-3-yl)benzamide; CHEMBL379553; 171628-57-2; N-{2-phenylimidazo[1,2-a]pyridin-3-yl}benzamide; AC1LF77Z; Oprea1_830806; MLS001162915; CTK0E4651; DTXSID60353680; MolPort-002-132-975; HMS2842E11; ZINC193750; BDBM50187634; STK367224; AKOS001415177; MCULE-3771425109; SMR000495823; SR-01000196826; N-(2-Phenylimidazo[1,2-a]pyridine-3-yl)benzamide; SR-01000196826-1; Benzamide, N-(2-phenylimidazo[1,2-a]pyridin-3-yl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 748028
CAS Number: CAS 171628-57-2
TTD Drug ID: DMUILX8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	3.621	1.888	3.567	4.318

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44.