Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMULZ4W)

Drug Name

CHR-2797 Drug Info

Synonyms

Tosedostat; Tosedostat, CHR2797, CHR-2797

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 2	[1]
Myelodysplastic syndrome	2A37	Phase 2	[2]
Inflammation	1A00-CA43.1	Terminated	[3]

Therapeutic Class

Anticancer Agents

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aminopeptidase (AMP)	TTWLEZV	NOUNIPROTAC	Inhibitor	[2]
Puromycin-sensitive aminopeptidase (NPEPPS)	TT371QC	PSA_HUMAN	Inhibitor	[4]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Puromycin-sensitive aminopeptidase (NPEPPS)	DTT	NPEPPS	6.142	6.779	6.6	6.838

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Acute myeloid leukaemia

ICD Disease Classification

2A60

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Puromycin-sensitive aminopeptidase (NPEPPS)	DTT	NPEPPS	8.88E-01	7.78E-03	1.30E-02

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022187)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014340)
4	CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 Aug 15;68(16):6669-79.