Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUOYQR)

Drug Name
AVI-5126 Drug Info
Synonyms Resten-CP; NeuGene (CABG), AVI
Indication
Disease Entry ICD 11 Status REF
Coronary artery disease BA80 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMUOYQR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Myc messenger RNA (MYC mRNA) TTNQ5ZP MYC_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Myc messenger RNA (MYC mRNA) DTT MYC 8.391 7.972 6.042 7.381
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 11 Disease of the circulatory system
Disease Class ICD-11: BA80 Coronary artery disease
The Studied Tissue Peripheral blood
The Studied Disease Coronary artery disease [ICD-11:BA80-BA8Z]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Myc messenger RNA (MYC mRNA) DTT MYC 6.09E-01 0.25 0.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00451256) Safety and Efficacy Study of AVI-5126 When Used on Vein Grafts Before Use in Heart by-Pass Graft Surgery (CABG). U.S. National Institutes of Health.
2 Efficacy of a phosphorodiamidate morpholino oligomer antisense compound in the inhibition of corneal transplant rejection in a rat cornea transplant model. J Ocul Pharmacol Ther. 2012 Apr;28(2):194-201.