Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUS0A4)

• Drug Name: 3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one Drug Info
• Synonyms: CHEMBL566982; SCHEMBL4421269; 3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one; IQXQUXAACBOTRO-UHFFFAOYSA-N; ZINC45245855; BDBM50299884

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 45483822
  TTD Drug ID: DMUS0A4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Progesterone receptor (PGR)	DTT	PGR	1.848	1.888	1.263	0.138

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Progesterone receptor (PGR)	DTT	PGR	3.26E-38	-3.79	-2.5

References

• [1] 5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6666-9.