Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMV0C69)

Drug Name

6-chlorotacrine hydrochloride Drug Info

Synonyms

6-chlorotacrine; 5778-84-7; 9-AMINO-6-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE; Tacrine Analogue 4; 6-chlorotacrine.HCl; 6-Chlorotacrine HCl; 6-chloro-1,2,3,4-tetrahydroacridin-9-amine; SCHEMBL4271238; BDBM8987; ZINC5689; CHEMBL292314; GQZMDBQRGRRPMS-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10399068
TTD Drug ID: DMV0C69

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acetylcholinesterase (AChE)	DTT	ACHE	1.678	1.926	1.766	5.252

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acetylcholinesterase (AChE)	DTT	ACHE	6.39E-02	-1.07	-1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009 Sep 10;52(17):5365-79.