General Information of Drug (ID: DMV19K7)

Drug Name
TRYPTOLINE Drug Info
Synonyms
16502-01-5; Tryptoline; 2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole; Noreleagnine; 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole; 1,2,3,4-Tetrahydro-beta-carboline; Tetrahydro-beta-carboline; THBC; Tetrahydronorharman; UNII-65027TMI0H; 1H,2H,3H,4H,9H-Pyrido[3,4-B]Indole; 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-; 2,3,4,9-tetrahydro-1H-beta-carboline; MLS000069483; CHEMBL269236; 65027TMI0H; SMR000059115; Triptoline; Tetrahydronorharmane; Tetrahydro-beta-carboline, 98%; 1,2,3,4-tetrahydrobeta-carboline
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
107838
ChEBI ID
CHEBI:92568
CAS Number
CAS 16502-01-5
TTD Drug ID
DMV19K7

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [2]
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Monoamine oxidase type B (MAO-B) DTT MAOB 9.367 6.907 8.237 8.409
Monoamine oxidase type A (MAO-A) DTT MAOA 7.207 8.159 9.043 7.711
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type B (MAO-B) DTT MAOB 2.65E-02 1.12E-02 0.07
Monoamine oxidase type A (MAO-A) DTT MAOA 8.14E-01 0.05 0.1
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.
2 Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5.