Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMV48S2)

Drug Name

PYROVALERONE Drug Info

Synonyms

Centroton; Thymergix; PYROVALERONE HYDROCHLORIDE; Pyrovalerone HCl; Sp 1059; Pyrovalerone hydrochloride [USAN]; EINECS 214-556-9; F 1983; 1147-62-2; 4'-Methyl-2-(1-pyrrolidinyl)valerophenone hydrochloride; 1-(p-Methylphenyl)-2-pyrrolidyl-1-pentanone hydrochloride; DEA No. 1485; 1-p-Tolyl-1-oxo-2-pyrrolidino-n-pentane hydrochloride; Valerophenone, 4'-methyl-2-(1-pyrrolidinyl)-, hydrochloride; 1-Pentanone, 1-(4-methylphenyl)-2-(1-pyrrolidinyl)-, hydrochloride; Pyrovalerone hydrochloride (USAN); AC1L23PD; SCHEMBL121638

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 14373
ChEBI ID: CHEBI:134998
CAS Number: CAS 3563-49-3
TTD Drug ID: DMV48S2
VARIDT Drug ID: DR00965

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[2]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7
Norepinephrine transporter (NET)	DTT	SLC6A2	2.459	3.426	3.322	3.35
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorg Med Chem. 2009 Jun 1;17(11):3770-4.
2	1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32.