Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMVSNPB)

Drug Name

4-benzhydryl-N-butylpiperazine-1-carboxamide Drug Info

Synonyms

4-benzhydryl-N-butylpiperazine-1-carboxamide; CHEMBL1087032; 681801-59-2; N-butyl-4-(diphenylmethyl)piperazine-1-carboxamide; (4-(DIPHENYLMETHYL)PIPERAZINYL)-N-BUTYLFORMAMIDE; AC1MDDX7; AC1Q2X1X; MLS001181725; MolPort-001-841-442; HMS2858M18; HMS1662P18; KS-000029IQ; BDBM50312580; ZINC19924797; AKOS022169771; MS-8361; MCULE-5902192289

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2809754
TTD Drug ID: DMVSNPB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[1]
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cannabinoid receptor 2 (CB2)	DTT	CNR2	7.037	6.733	6.944	7.163
Cannabinoid receptor 1 (CB1)	DTT	CNR1	2.907	4.667	2.982	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 1 (CB1)	DTT	CNR1	5.59E-02	-0.22	-0.45
Cannabinoid receptor 1 (CB1)	DTT	CNR1	7.68E-01	-0.06	-0.46

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9.