Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWIALU)

Drug Name
4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid Drug Info
Synonyms
4-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-benzoic acid; 4-[(2-oxochromen-3-yl)carbonylamino]benzoic acid; 4-{[(2-oxo-2H-chromen-3-yl)carbonyl]amino}benzoic acid; BAS 00518567; AC1MJCO7; 3-carboxamido coumarin, 19; Oprea1_826423; Oprea1_127959; CHEMBL513209; SCHEMBL4389144; BDBM29169; MolPort-000-375-260; ZINC3076649; STL353172; SBB041117; BBL026015; AKOS000269615; MCULE-2534949799; ST50102584; 4-[(2-oxochromene-3-carbonyl)amino]benzoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3110315
TTD Drug ID
DMWIALU

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Monoamine oxidase type B (MAO-B) DTT MAOB 9.367 6.907 8.237 8.409
Monoamine oxidase type A (MAO-A) DTT MAOA 7.207 8.159 9.043 7.711
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type B (MAO-B) DTT MAOB 2.65E-02 1.12E-02 0.07
Monoamine oxidase type A (MAO-A) DTT MAOA 8.14E-01 0.05 0.1
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42.