Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWTFO3)

• Drug Name: IMAZODAN Drug Info
• Synonyms: IMAZODAN HYDROCHLORIDE; Imazodan HCl; CI-914; UNII-5EP74J9Q34; Imazodan hydrochloride [USAN]; 89198-09-4; 4,5-Dihydro-6-(p-imidazol-1-ylphenyl)-3(2H)-pyridazinone monohydrochloride; 5EP74J9Q34; 4,5-Dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-3(2H)-pyridazinone hydrochloride; Imazodan hydrochloride (USAN); 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-, monohydrochloride; 3(2H)-Pyridazinone, 4,5-dihydro-6-(p-(1-imidazolyl)phenyl)-, monohydrochloride; ACMC-20livl; AC1Q3ES0; C13H12N4O.HCl; SCHEMBL124243; AC1L1K29
• Cross-matching ID:
  PubChem CID: 55918
  CAS Number: CAS 84243-58-3
  TTD Drug ID: DMWTFO3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 2A (PDE2A)	TTJGW1Z	PDE2A_HUMAN	Inhibitor	[1]
Phosphodiesterase 3A (PDE3A)	TT06AWU	PDE3A_HUMAN	Inhibitor	[2]
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 5A (PDE5A)	DTT	PDE5A	3.632	3	3.632	4.271
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	4.717	6.087	5.051	5.051

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 5A (PDE5A)	DTT	PDE5A	3.24E-05	-0.07	-0.17
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	8.06E-01	-0.04	-0.15

References

• [1] Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of conges... J Med Chem. 1984 Sep;27(9):1099-101.
• [2] 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem. 1992 Feb 21;35(4):620-8.