Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMX34TL)

Drug Name

2-fluoronorepinehprine Drug Info

Synonyms

CHEMBL40317; Lopac-B-012; AC1O7G01; CTK2G6131; BDBM50087513; NCGC00015118-01; 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-5-fluoro-; 4-[(1R)-2-amino-1-hydroxyethyl]-5-fluorobenzene-1,2-diol; (R)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6603724
TTD Drug ID: DMX34TL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.09	5.67	5.558	5.603

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	4.88E-01	-0.05	-0.12
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.10E-01	0.06	0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. Bioorg Med Chem. 2009 Dec 1;17(23):7987-92.