Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMX8DZM)

Drug Name

7-chloro-1H-indazole Drug Info

Synonyms

7-chloro-1H-indazole; 37435-12-4; 7-Chloroindazole; 1H-Indazole, 7-chloro-; CHEMBL247367; AK-24465; 7-chlor-1H-indazol; ACMC-1AG86; SCHEMBL104360; SCHEMBL19152469; CTK1C1806; DTXSID80455690; WIYOYUQVNPTVQG-UHFFFAOYSA-N; MolPort-001-767-757; 7-Chloro-1H-indazole, AldrichCPR; ZX-AT002536; BCP27378; BDBM50209244; ZINC12336533; STL554161; SBB054730; MFCD07368214; ANW-28635; OR3680; FCH921470; BBL100367; AKOS024124979; AKOS005072025; VI20076; RP01758; MCULE-5657266195; CB-0833; PB17411; ACM37435124; KB-46237; SC-27673; QC-11238; BL000561; AN-17144

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11116249
CAS Number: CAS 37435-12-4
TTD Drug ID: DMX8DZM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	5.20E-01	0.02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80.