Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXHW91)

Drug Name

SDZ-SER-082 Drug Info

Synonyms

SDZ SER-082; Biomol-NT_000136; GTPL195; CHEMBL316069; BPBio1_000024; SCHEMBL13073064; BDBM85099; ZINC16077; SER-082; CAS_141474-54-6; BRD-K31339597-051-01-2

Indication

Disease Entry	ICD 11	Status	REF
Neurological disorder	6B60	Terminated	[1]

Cross-matching ID

PubChem CID: 9859407
CAS Number: CAS 141474-54-6
TTD Drug ID: DMXHW91

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2C receptor (HTR2C)	DTT	HTR2C	4.233	3.329	3.843	3.888

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Neurological disorder

ICD Disease Classification

6B60

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2C receptor (HTR2C)	DTT	HTR2C	1.02E-02	-0.45	-0.37
5-HT 2C receptor (HTR2C)	DTT	HTR2C	2.27E-01	0.27	0.6

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 195).
2	Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain Res. 2005 Apr 8;1040(1-2):64-72.