Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXHWK6)

Drug Name
Neutralase Drug Info
Synonyms Heparinase I, IBEX
Indication
Disease Entry ICD 11 Status REF
Angiogenesis disorder BE2Z Discontinued in Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMXHWK6

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heparanase (HPSE) TTR7GJO HPSE_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Heparanase (HPSE) DTT HPSE 4.848 5.82 5.433 5.278
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Angiogenesis disorder
ICD Disease Classification BE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Heparanase (HPSE) DTT HPSE 8.10E-01 0.19 0.23
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007559)
2 Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin. J Thromb Haemost. 2006 Mar;4(3):560-5.