Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXQ47M)

Drug Name

(S)-WILLARDIINE Drug Info

Synonyms

(S)-WILLARDIINE; Willardiine; S(-)-Willardiine; 21416-43-3; 3-(Uracil-1-yl)-L-alanine; (-)-Willardiine; CHEMBL122005; CHEBI:15851; 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine; HWD; 2-AMINO-3-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID; 1mqj; 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)alanine; AC1L98KY; Lopac0_001219; SCHEMBL401191; SCHEMBL13319907; BDBM17661; CTK5H8581; MolPort-003-959-938; ZINC901774; 96108-98-4; 2990AH; AKOS006281897; DB04129; CCG-205293; CS-3618; NCGC00094464-03; HY-12499; EU-0101219; C03584

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 440053
ChEBI ID: CHEBI:15851
CAS Number: CAS 21416-43-3
TTD Drug ID: DMXQ47M

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Inhibitor	[1]
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glutamate receptor AMPA 1 (GRIA1)	DTT	GRIA1	3.209	3.365	3.194	3.379
Glutamate receptor AMPA (GRIA)	DTT	GRIA	3.07	2.907	2.945	3.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA 1 (GRIA1)	DTT	GRIA1	1.46E-06	-0.63	-0.78
Glutamate receptor AMPA (GRIA)	DTT	NO-GeName	1.79E-04	-0.69	-0.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem. 1997 Oct 24;40(22):3645-50.