Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXYHC7)

• Drug Name: RU-101 Drug Info
• Synonyms: RU-10; Recombinant human serum albumin (ocular, dry eye), R-Tech Ueno

Indication

Disease Entry	ICD 11	Status	REF
Xerophthalmia	5B55.Y	Phase 1/2	[1]

• Cross-matching ID: TTD Drug ID: DMXYHC7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serum albumin (ALB)	TTFNGC9	ALBU_HUMAN	Modulator	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serum albumin (ALB)	DTT	ALB	7.535	2.536	4.755	4.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Xerophthalmia
• ICD Disease Classification: 5B55.Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serum albumin (ALB)	DTT	ALB	7.92E-01	-0.07	-0.44

References

• [1] ClinicalTrials.gov (NCT01843894) A Phase 1/2, RU-101 Ophthalmic Solution in Patients With Severe Dry Eye. U.S. National Institutes of Health.
• [2] Albumin as a tear supplement in the treatment of severe dry eye. Br J Ophthalmol. 2003 October; 87(10): 1279-1283.