Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMY3BMC)

• Drug Name: IPH-3102 Drug Info
• Synonyms: IPH-31XX; TLR-3 receptor agonist (cancer), Innate Pharma; Toll-like receptor 3 agonist (cancer),Innate Pharma

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

• Cross-matching ID: TTD Drug ID: DMY3BMC

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 3 (TLR3)	TTD24Y0	TLR3_HUMAN	Agonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Toll-like receptor 3 (TLR3)	DTT	TLR3	4.256	5.833	5.916	6.583

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Solid tumour/cancer
• ICD Disease Classification: 2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Toll-like receptor 3 (TLR3)	DTT	TLR3	4.85E-01	0.63	0.83
Toll-like receptor 3 (TLR3)	DTT	TLR3	8.00E-01	0.11	0.1

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037691)
• [2] Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.