Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYAS2V)

Drug Name

6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine Drug Info

Synonyms

CHEMBL473662; 6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine; BAS 06575347; AC1LFG9R; 2,4-Pyrimidinediamine, 6-(4-methyl-1-piperazinyl)-; SCHEMBL2169898; MolPort-002-005-545; ZINC205303; BDBM50304501; CCG-24528; AKOS000670805; 4940-96-9; VU0047515-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 753256
TTD Drug ID: DMYAS2V

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H4 receptor (H4R)	DTT	HRH4	5.238	4.933	4.347	4.022

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H4 receptor (H4R)	DTT	HRH4	1.32E-01	0.1	0.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96.