Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYDX34)

Drug Name

N-Hydroxy-2-naphthalen-2-yl-acetamide Drug Info

Synonyms

N-hydroxy-2-(naphthalen-2-yl)acetamide; CHEMBL346935; 106359-52-8; 2-Naphthaleneacetamide, N-hydroxy-; N-Hydroxy-2-naphthalen-2-yl-acetamide; AC1Q7DIT; SCHEMBL1520280; CTK8A6801; MolPort-004-327-963; KUC108662N; ZINC19423737; BDBM50015114; AKOS000168393; NE14616; MCULE-5699071643; NCGC00186600-01; NCGC00186600-02; KSC-11-264-7

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 24689999
TTD Drug ID: DMYDX34

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8.