Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYF8ES)

Drug Name

1-(2-bromoethyl)-1H-indole-2,3-dione Drug Info

Synonyms

1-(2-bromoethyl)-1H-indole-2,3-dione; 4290-78-2; 1-(2-Bromoethyl)indoline-2,3-dione; 1-(2-bromoethyl)-2,3-dihydro-1H-indole-2,3-dione; AC1MSZWL; 1-(2-bromoethyl)isatin; Isatin-based compound, 5; 1H-Indole-2,3-dione, 1-(2-bromoethyl)-; CHEMBL223000; SCHEMBL10685462; TOS-BB-0914; BDBM22785; CTK4I6774; DTXSID90393478; MolPort-000-453-141; SJALPCXFOSGNST-UHFFFAOYSA-N; ZINC2668691; 1-(2-bromoethyl)indole-2,3-dione; STK866424; BBL023389; 1-(2-bromoethyl)-indole-2,3-dione; AKOS000245669; MCULE-3160954506; KB-85508; AJ-44119

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3542734
CAS Number: CAS 4290-78-2
TTD Drug ID: DMYF8ES

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85.