Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYTS73)

Drug Name

Phenyl-N,N-bis(tosylmethyl)methanamine Drug Info

Synonyms

CHEMBL399303; phenyl-N,N-bis(tosylmethyl)methanamine; Benzylbis[(4-methylbenzenesulfonyl)methyl]amine; 65950-40-5; AC1MXBV6; SCHEMBL3972986; CTK1I1277; DTXSID60396416; ZINC15776492; BDBM50232467; AKOS027445593; N,N-Bis(tosylmethyl)benzenemethanamine; N,N-bis[(4-methylphenyl)sulfonylmethyl]-1-phenylmethanamine; Benzenemethanamine, N,N-bis[[(4-methylphenyl)sulfonyl]methyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3787955
CAS Number: CAS 65950-40-5
TTD Drug ID: DMYTS73

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Melanin-concentrating hormone receptor 1 (MCHR1)	DTT	MCHR1	4.392	4.823	5.433	5.725

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Melanin-concentrating hormone receptor 1 (MCHR1)	DTT	MCHR1	6.98E-01	-0.01	-0.04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening. J Med Chem. 2008 Feb 14;51(3):581-8.