Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ5A6D)

Drug Name
GSK2398852 Drug Info
Synonyms 2398852
Indication
Disease Entry ICD 11 Status REF
Amyloidosis 5D00 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMZ5A6D

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serum amyloid P-component (APCS) TTB7VAT SAMP_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Serum amyloid P-component (APCS) DTT APCS 12.393 5.113 5.459 5.182
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Amyloidosis
ICD Disease Classification 5D00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serum amyloid P-component (APCS) DTT APCS 3.02E-01 -0.06 -0.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8255).
2 ClinicalTrials.gov (NCT01777243) A Study to Evaluate the Safety of GSK2398852 When Co-administered With GSK2315698 in Patients With Systemic Amyloidosis. U.S. National Institutes of Health.