Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ5MDY)

Drug Name
5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide Drug Info
Synonyms
CHEMBL290395; 5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide; SCHEMBL8527508; BYXYRVSXGVLRKM-UHFFFAOYSA-N; BDBM50321877; 5-Chloro-1-(3-pyridylcarbamoyl)indoline; N-(3-Pyridinyl)-5-chloro-2,3-dihydro-1H-indole-1-carboxamide; 5-Chloro-2,3-dihydro-indole-1-carboxylic acid pyridin-3-ylamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10826147
TTD Drug ID
DMZ5MDY

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [1]
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 2C receptor (HTR2C) DTT HTR2C 4.233 3.329 3.843 3.888
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 2C receptor (HTR2C) DTT HTR2C 1.02E-02 -0.45 -0.37
5-HT 2C receptor (HTR2C) DTT HTR2C 2.27E-01 0.27 0.6
5-HT 2A receptor (HTR2A) DTT HTR2A 1.68E-01 -0.3 -0.14
5-HT 2A receptor (HTR2A) DTT HTR2A 5.59E-01 0.15 0.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92.