Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ5RA7)

Drug Name

TRK-851 Drug Info

Synonyms

(4bS,8R,8aS,16bR)-7-(Cyclopropylmethyl)-11-fluoro-5,6,7,8,9,14,15,16b-octahydro-4,8-methano-8aH,13H-[1]benzofuro[2,3-a]dipyrido[4,3-b:3',2',1'-jk]carbazole-1,8a-diol; 189015-25-6

Indication

Disease Entry	ICD 11	Status	REF
Cough	MD12	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 11691355
TTD Drug ID: DMZ5RA7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor delta (OPRD1)	TT27RFC	OPRD_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Opioid receptor delta (OPRD1)	DTT	OPRD1	2.848	2.263	1.536	2

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cough

ICD Disease Classification

MD12

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Opioid receptor delta (OPRD1)	DTT	OPRD1	5.52E-01	0.03	0.23

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015232)
2	Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851. Bioorg Med Chem. 2008 Sep 1;16(17):7956-67.