Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ6YPV)

Drug Name
cyamemazine Drug Info
Synonyms cyamepromazine; RP-7204
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
62865
ChEBI ID
CHEBI:135379
CAS Number
CAS 3546-03-0
TTD Drug ID
DMZ6YPV
INTEDE Drug ID
DR0388

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Antagonist [2]
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Antagonist [2]
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Antagonist [2]
5-HT 7 receptor (HTR7) TTO9X1H 5HT7R_HUMAN Antagonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Investigative [3]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Investigative [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Investigative [3]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Investigative [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 2C receptor (HTR2C) DTT HTR2C 4.233 3.329 3.843 3.888
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
5-HT 7 receptor (HTR7) DTT HTR7 1.561 1.233 0.848 1.485
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 9.791 3.744 3.413 1.609
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 10.036 5.779 6.508 6.481
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 11.76 5.931 6.164 9.423
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 11.692 6.58 4.984 9.089
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 2.18E-01 -0.11 -0.51
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 1.14E-01 7.49E-02 1.11E+00
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 5.03E-01 -2.08E-03 -9.42E-03
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 1.78E-01 -1.19E-01 -1.50E+00
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 4.96E-02 5.36E-01 1.70E+00
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 9.31E-01 2.00E-02 1.82E-01
Cytochrome P450 2C9 (CYP2C9) DME CYP2C9 2.00E-01 4.21E-02 3.26E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 3.18E-03 2.30E-01 2.71E+00
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 8.32E-01 4.74E-02 1.73E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 84).
2 Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40.
3 Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66.