Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ7GUP)

Drug Name
1-hydroxy-3-(4-nitrophenyl)urea Drug Info
Synonyms 1-hydroxy-3-(4-nitrophenyl)urea; CHEMBL259979; 53731-88-7; NSC163567; AC1NQIZ7; SCHEMBL16005844; CTK1H3407; DTXSID10411168; BDBM50377113
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5222748
CAS Number
CAS 53731-88-7
TTD Drug ID
DMZ7GUP

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tyrosinase (TYR) DTT TYR 5.959 5.711 5.973 4.912
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosinase (TYR) DTT TYR 6.68E-04 2.54 1.15
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10.