Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ8Y67)

Drug Name
Beta-naphthylboronic acid Drug Info
Synonyms
2-Naphthaleneboronic acid; 32316-92-0; Naphthalen-2-ylboronic Acid; 2-Naphthylboronic acid; Naphthalene-2-boronic acid; 2-naphthalene boronic acid; 2-naphthaleneylboronic acid; Naphthalenyl-2-boronic acid; 2-Naphtahaleneboronic acid; beta-naphthylboronic acid; Naphthalen-2-boronic acid; Naphthalen-2-Yl-Boranediol; 2-NAPHTHYLBORONIC CAID; Boronic acid, 2-naphthalenyl-; (naphthalen-2-yl)boronic acid; CHEMBL141079; MFCD00236051; NAPHTHALEN-2-YL-2-BORONIC ACID; 2-Naphthaleneboronic acid, 97+%; Naphthalene-2-boronicacid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2734375
CAS Number
CAS 32316-92-0
TTD Drug ID
DMZ8Y67

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5.