Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZB804)

Drug Name

3-(4-Trifluoromethylphenyl)-2-nortropene Drug Info

Synonyms

CHEMBL570871; (+/-)-3-(4-trifluoromethylphenyl)-8-azabicyclo(3.2.1]oct-2-ene; (+/-)-3-(4-trifluoromethylphenyl)-8-azabicyclo[3.2.1]oct-2-ene; 3-(4-Trifluoromethylphenyl)-2-nortropene; SCHEMBL6577750; TVAPTTJJXRUWFI-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9816454
TTD Drug ID: DMZB804

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8.