Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZL48U)

Drug Name

KUR-111 Drug Info

Synonyms

I-0401; I-040302; TGplPTH1-34; Fibrin-PTH (bone cysts), Kuros; Human parathyroid hormone (PTH) + TISSEEL fibrin sealant + hydroxyapatite/tri-calcium phosphate granules (bone fracture), Kuros/Baxter

Indication

Disease Entry	ICD 11	Status	REF
Bone disease	FC0Z	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMZL48U

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Parathyroid hormone (PTH)	TT6F7GZ	PTHY_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Parathyroid hormone (PTH)	DTT	PTH	-0.737	1.485	1.322	0

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Bone disease

ICD Disease Classification

FC0Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Parathyroid hormone (PTH)	DTT	PTH	3.70E-01	0.08	0.66

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00459641) Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts. U.S. National Institutes of Health.
2	Company report (Cytos)