Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZY72I)

Drug Name

2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-one Drug Info

Synonyms

87372-75-6; 2-Methyl-1-phenyl-2-(3-pyridinyl)-1-propanone; CHEMBL294460; 2-Mppp; 2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-one; AC1L37C5; SCHEMBL12260655; CTK5F8302; DTXSID50236312; ZINC5138212; BDBM50028170; KB-231336; 2-methyl-1-phenyl-2-pyridin-3-ylpropan-1-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 135918
CAS Number: CAS 87372-75-6
TTD Drug ID: DMZY72I

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9.