Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM09GSW)

Drug Name
Abafungin Drug Info
Synonyms
Abasol; W-634; YP-006; YP-007; Abafungin (gel formulation), York Pharma; Abafungin (cream, dermatomycosis), York Pharma; Abafungin (gel formulation, onychomycosis), York Pharma; Abafungin (pessary, vaginal candidiasis), York Pharma
Indication
Disease Entry ICD 11 Status REF
Fungal infection 1F29-1F2F Discontinued in Phase 3 [1]
Cross-matching ID
PubChem CID
159326
ChEBI ID
CHEBI:76005
CAS Number
CAS 129639-79-8
TTD Drug ID
DM09GSW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Candida Cytochrome P450 51 (Candi ERG11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [3]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [3]
Posaconazole DMUL5EW Aspergillosis 1F20 Approved [4]
Ketoconazole DMPZI3Q Blastomycosis 1F22 Approved [5]
Miconazole DMPMYE8 Cutaneous candidiasis 1F23.14 Approved [3]
Oxiconazole DME7KRM Tinea corporis 1F28.Y Approved [6]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [3]
Terconazole DMJ13KI Candidiasis 1F23 Approved [7]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [8]
Tioconazole DMNYPGS Onychomycosis EE12.1 Approved [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022887)
2 Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Mol Biochem Parasitol. 2005 Nov;144(1):68-75.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity. Mycoses. 2006;49 Suppl 1:2-6.
5 Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
6 Antifungal agents: mechanisms of action. Trends Microbiol. 2003 Jun;11(6):272-9.
7 Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9.
8 Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7.
9 Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6.