Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0EKUQ)

Drug Name

NY-ESO-1 vaccine Drug Info

Synonyms

Cancer vaccine (peptides), Ludwig Institute; NY-ESO-1b; NY-ESO-1 OLP-4; NY-ESO-1 peptide immunotherapy, Ludwig Institute; NY-ESO-1 vaccine (peptides); NY-ESO-1 DP4 peptide (157-170); NY-ESO-1 vaccine (peptides), Ludwig Institute

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM0EKUQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Cancer/testis antigen 1 (NY-ESO-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CDX-1401	DMCGNJ6	Ovarian cancer	2C73	Phase 2	[3]
CV-9201	DMCPZYT	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[4]
Anti-NY-ESO-1 CAR-T cells	DM26VCZ	Esophageal cancer	2B70	Phase 1/2	[5]
GSK-2241658A	DM5VS7B	Melanoma	2C30	Phase 1	[6]
GSK3901961	DMN4I7P	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
GSK3845097	DM1UQ4Y	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
Melanoma vaccine (ALVAC)	DM3HIQY	Melanoma	2C30	Discontinued in Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cancer/testis antigen 1 (NY-ESO-1)	TTE5ITK	CTG1B_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00199836) A Pilot Study of NY-ESO-1b Peptide Plus CpG 7909 and Montanide ISA-51 in Patients With Cancer.. U.S. National Institutes of Health.
2	Multiepitope CD8+ T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting. J Clin Invest. 2002 December 15; 110(12): 1813-1822.
3	National Cancer Institute Drug Dictionary (drug id 651880).
4	National Cancer Institute Drug Dictionary (drug id 648549).
5	ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies
6	ClinicalTrials.gov (NCT01213472) Evaluation of a New Anti-cancer Immunotherapy in Patients With Non-operable and Progressing Metastatic Cutaneous Melanoma. U.S. National Institutes of Health.
7	Clinical pipeline report, company report or official report of GlaxoSmithKline.
8	Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58.