Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0LQ94)

Drug Name
GnRH Drug Info
Synonyms
Lutrepatch; GnRH (Lutrepatch, female fertility); GnRH (Lutrepatch, female fertility), Ferring; GnRH (Lutrepatch, female infertility), Ferring/Vyteris; GnRH (Smart Patch, female infertility), Ferring/Vyteris; GnRH (Smart Patch, female infertility), Vyteris/Ferring; Iontophoretic anti-infertility peptide (Smart Patch), Ferring/Vyteris; Iontophoretic anti-infertility peptide (Smart Patch), Vyteris/Ferring; Anti-infertility peptide (iontophoretic/Smart Patch), Ferring/Vyteris; Anti-infertility peptide (iontophoretic/Smart Patch), Vyteris/Ferring; Gonadotropin-releasing hormone (Smart Patch, female infertility), Ferring/Vyteris; Gonadotropin-releasing hormone (Smart Patch, female infertility), Vyteris/Ferring
Indication
Disease Entry ICD 11 Status REF
Female infertility GA31.Z Phase 3 [1]
Cross-matching ID
PubChem CID
16132914
TTD Drug ID
DM0LQ94

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Gonadotropin-releasing hormone receptor (GNRHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gonadorelin DMAQ469 Amenorrhea GA20.0 Approved [3]
Relugolix DMK7IWL Prostate cancer 2C82.0 Approved [4]
Ganirelix DMGMB30 Ovulation dysfunction 5A80 Approved [5]
Abarelix DM5WFNP Prostate cancer 2C82.0 Approved [6]
Triptorelin DMTK4LS Infertility GB04 Approved [7]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [8]
Nafarelin DMAHEFY Endometriosis GA10 Approved [9]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [10]
Elagolix sodium DMRDUC0 Endometriosis GA10 Approved [11]
Degarelix DM3O8QY Prostate cancer 2C82.0 Approved [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gonadotropin-releasing hormone receptor (GNRHR) TT8R70G GNRHR_HUMAN Modulator [2]

References

1 Clinical pipeline report, company report or official report of Ferring Pharmaceuticals Inc.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256).
3 Use of cognitive behavior therapy for functional hypothalamic amenorrhea. Ann N Y Acad Sci. 2006 Dec;1092:114-29.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
5 Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibiti... J Clin Endocrinol Metab. 2007 Sep;92(9):3626-32.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7 Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1. Endocrine. 2006 Aug;30(1):139-44.
8 Clinical pipeline report, company report or official report of Takeda (2009).
9 Reversible downregulation of endocrine and germinative testicular function (hormonal castration) in the dog with the GnRH-agonist azagly-nafarelin ... Theriogenology. 2009 Apr 15;71(7):1037-45.
10 Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation in primary cell cultures of human prostatic adenocarcinomas. Prostate. 2009 Jul 1;69(10):1025-33.
11 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
12 Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II. J Med Chem. 2005 Jul 28;48(15):4851-60.