Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0POWG)

Drug Name
Vidofludimus Drug Info
Synonyms
Vidofludimus; 717824-30-1; 4SC-101; UNII-8Y1PJ3VG81; SC12267; Vidofludimus(4SC-101; SC12267); CHEMBL197194; 8Y1PJ3VG81; 2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic Acid; 2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}cyclopent-1-ene-1-carboxylic acid; 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid; Vidofludimus [INN]; SC 12267; SCHEMBL247888; GTPL9860; KS-00000TTT; BDBM16111; EX-A546; DTXSID50431325; MolPort-039-193-851; BCP14555; AOB87354; s7262; ZINC14960644
Indication
Disease Entry ICD 11 Status REF
Inflammatory bowel disease DD72 Phase 2 [1]
Rheumatoid arthritis FA20 Phase 2 [1]
Cross-matching ID
PubChem CID
9820008
CAS Number
CAS 717824-30-1
TTD Drug ID
DM0POWG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dihydroorotate dehydrogenase (DHODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [3]
BREQUINAR DMKGM42 Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
BAY2402234 DMRL6W5 Myeloid leukaemia 2B33.1 Phase 1 [5]
LAS-186323 DMV80DP Multiple sclerosis 8A40 Phase 1 [6]
HR325 DM51GZS Rheumatoid arthritis FA20 Discontinued in Phase 2 [7]
FK778 DMH6QAI Kidney/heart transplant rejection NE84 Discontinued in Phase 2 [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dihydroorotate dehydrogenase (DHODH) TTLVP78 PYRD_HUMAN Modulator [2]

References

1 2011 Pipeline of 4SC AG.
2 Company report (4SC)
3 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4 DOI: 10.1203/00006450-198807000-00137
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Clinical pipeline report, company report or official report of Aslanpharma.
7 In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42.
8 Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9.