Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0QGF3)

Drug Name
MRS2279 Drug Info
Synonyms
LPZJKPSGEADHTQ-HLTSFMKQSA-N; [(1S,2R,4R)-4-[(2-chloro-6-methylaminopurin-9-yl)methyl]-2-(phosphonooxymethyl)cyclopentyl] dihydrogen phosphate; [3H]MRS2279; [3H]-MRS2279; AC1NSKE5; GTPL1727; GTPL1721; [(1R,2S,4R)-4-[[2-chloro-6-(methylamino)purin-9-yl]methyl]-2-phosphonooxycyclopentyl]methyl dihydrogen; MRS-2279
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5311301
TTD Drug ID
DM0QGF3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting P2Y purinoceptor 1 (P2RY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
adenosine diphosphate DMFUHKP N. A. N. A. Investigative [2]
2MeSATP DMUE0W6 Discovery agent N.A. Investigative [2]
PPADS DMWHN3T Discovery agent N.A. Investigative [2]
2MeSADP DMGADQ1 Discovery agent N.A. Investigative [3]
ATPgammaS DMXHQIN Discovery agent N.A. Investigative [4]
2',3'-ddATP DMOB7P6 Discovery agent N.A. Investigative [4]
[35S]ADPbetaS DMAYPTO Discovery agent N.A. Investigative [5]
MRS2298 DMZ6EGA Discovery agent N.A. Investigative [6]
MRS2500 DMNGTOY Discovery agent N.A. Investigative [7]
2,2'-pyridylisatogen tosylate DMOQDBA Discovery agent N.A. Investigative [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
P2Y purinoceptor 1 (P2RY1) TTA93TL P2RY1_HUMAN Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1727).
2 Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57.
3 Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9.
4 An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 323).
6 Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002.
7 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J Med Chem. 2003 Nov 6;46(23):4974-87.
8 2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding. Biochem Pharmacol. 2004 Jul 15;68(2):231-7.