Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0U8IV)

Drug Name

hyp 9 Drug Info

Synonyms

2,4-(1-keto-hexyl) phloroglucinol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Short transient receptor potential channel 6 (TRPC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[3]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[3]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[3]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[4]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[3]
flufenamate	DMN8AP0	Discovery agent	N.A.	Investigative	[3]
SAG	DMHOG7W	Discovery agent	N.A.	Investigative	[4]
ML9	DMP13VE	Discovery agent	N.A.	Investigative	[3]
SLG	DMEBPCO	Discovery agent	N.A.	Investigative	[4]
20-HETE	DM5BAJ9	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Short transient receptor potential channel 6 (TRPC6)	TTRBT3W	TRPC6_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4101).
2	Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).
4	Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.