Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1F50I)

Drug Name

ABT-110 Drug Info

Synonyms

Hu-alphaD11; PG-110; Humanized anti-NGF antibody (pain), Lay Line Genomics; Humanized anti-NGF antibody (pain), PanGenetics; Humanized anti-nerve growth factor antibody (pain), Lay Line Genomics; Humanized anti-nerve growth factor antibody (pain), PanGenetics

Indication

Disease Entry	ICD 11	Status	REF
Chronic pain	MG30	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM1F50I

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tanezumab	DMJKWMA	Cancer related pain	MG30	Phase 3	[3]
Fasinumab	DM5PRLA	Chronic low back pain	MG30.02	Phase 3	[3]
SAR164877	DMOJLCV	Pain	MG30-MG3Z	Phase 2/3	[2]
CERE-110	DMNW5I9	Alzheimer disease	8A20	Phase 2	[4]
CXB-909	DMUGMFN	Neurodegenerative disorder	8A20-8A23	Phase 1/2	[5]
NsG-0202	DM1ITDN	Alzheimer disease	8A20	Phase 1	[5]
MEDI-578	DMPW21Z	Pain	MG30-MG3Z	Phase 1	[2]
Nerve growth factor	DMHYQ8K	Alzheimer disease	8A20	Terminated	[6]
------------------------------------------------------------------------------------


⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nerve growth factor (NGF)	TTDN3LF	NGF_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT00941746) Safety and Tolerability of PG110 in Patients With Knee Osteoarthritis Pain. U.S. National Institutes of Health.
2	Fate of novel painkiller mAbs hangs in balance.Nat Biotechnol.2011 Mar;29(3):173-4.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Curr Opin Mol Ther. 2010 Apr;12(2):240-7.
5	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.